Profhilo® Structura: My Results, Side Effects & Expert Advice

After hearing the buzz, I had to try Profhilo® Structura for myself. I’ve tested plenty of skin boosters and injectables over the years, but this one promised more than plumping. It’s designed to restore fat pads and structure to ageing skin. I booked a consultation with the fabulous Dr Raquel at All Saint Skin Clinic — here’s exactly what happened.

What is Profhilo® Structura and how is it different to traditional fillers?

Profhilo® Structura is a next-gen injectable that helps regenerate fat tissue and improve skin structure, unlike traditional fillers that only add volume. It targets deeper layers to restore natural contours, offering gradual, natural-looking results.

Injectables used to be about instant plump: fill the line, volumise the cheek, smooth the crease. But the latest innovation taking off in elite skin clinics across Australia is a subtler, deeper kind of enhancement. Rather than simply camouflaging volume loss, Profhilo® Structura works to restore what time has taken, encouraging regeneration of the facial fat pads that give our faces structure, shape, and softness. Intrigued? So was I.

After hearing promising reviews from my trusted circle of fellow beauty editors—and noticing that more dermatologists and cosmetic doctors were quietly recommending it to patients wanting natural-looking support, I booked a consultation with Dr Raquel at All Saint Skin Clinic in Double Bay, a name synonymous with some of Sydney’s most discreetly enhanced faces.

How is Profhilo® Structura different from other injectables?

“It’s not a filler,” Dr Raquel was quick to clarify during my appointment. “It’s a regenerator.”

Unlike traditional hyaluronic acid fillers, which volumise by physically filling space, Profhilo® Structura uses Hybrid Cooperative Complex (HCC) technology to stimulate tissue repair at a deeper level. The injectable is placed into the subcutaneous fat layer, where facial fat pads naturally reside, and encourages the body to rebuild fat tissue, restore skin density, and restructure collagen and elastin.

In layman’s terms? It doesn’t just patch up the loss—it encourages your face to rebuild itself.

How is Profhilo® Structura different from other injectables?

One of the best things about Profhilo® Structura is how progressive and natural the results are. “Most patients see glowing skin improvements within a month,” says Dr Raquel. Think: better hydration, smoother texture, bounce and firmness—without a single drop of makeup. And there’s also an instant lift! Dr Raquel was quick to warn me that post treatment there’s swelling along the cheekbones that can make them look quite pronounced – which I rather enjoyed. I did have a few comments on instagram, people asking what I’d had done – just in that 48 hours following the procedure but then it settled and no one could see anything noticeable.

Over the following 2–4 weeks, most people notice more hydration and glow, tighter skin and improved texture. This is when I started having people ask me what skincare I’d been using.

Over 8–12 weeks, apparently you’ll see better elasticity and subtle volume return. I’m still only about 6 weeks out so I’ll let you know.

The most exciting part? “We see soft restoration of volume in areas like the cheeks and jawline, subtle lifting, and better definition without puffiness or that overly ‘done’ look,” she says.

And it doesn’t stop there. Tissue continues to remodel for up to 6 months, making this a slow-burn kind of beauty investment—one that truly pays off.

Which areas does it work best on?

Dr Raquel says it’s especially effective on the cheeks and jawline, the zones most affected by age-related fat loss and sagging.

What does the treatment feel like?

It is rather ouchy, so I opted for gas, which definitely helps take the edge off. But it’s over pretty quickly.

Does it work with other treatments?

Absolutely. Dr Raquel says Profhilo® Structura is often paired with Botox or anti-wrinkle injections for optimal results. “Botox relaxes expression lines, while Profhilo® Structura improves the skin’s underlying architecture,” she explains. “Together, they give you a refreshed but natural look—never stiff or puffy.”

My experience at All Saint Skin Clinic

Having been a regular at All Saint for years, I already knew I was in expert hands. Dr Raquel explained the process thoroughly, and offered the option of nitrous oxide (gas) for pain management, which I gladly accepted (for those less pain-tolerant: it helps a lot).

The treatment itself was swift—around 20 minutes—and involved a handful of deep injections via microcannula, mainly to my cheeks and jawline, where subtle hollowing had started to show. I experienced some tenderness and a slight ache in the hours afterwards. But no bruising, no downtime.

Within a week, I noticed my skin looking more hydrated and luminous. A month later? My cheekbones looked softly defined and my skin firmer.

Final Thoughts

If you’re after a ‘quiet luxury’ approach to injectables, Profhilo® Structura might just be your new secret weapon. It’s not about inflated lips or exaggerated volume—it’s about supporting your skin from within, with results that build over time and don’t scream you’ve had work done.

It’s also not a one-and-done. Most patients will need two sessions spaced a month apart, and ideally a maintenance treatment every 6–12 months. But for me, the subtle, regenerative effect—and the sheer quality of my skin afterwards—was more than worth it.

Profhilo® Structura is available at All Saint Skin Clinic in Double Bay. Consultations with Dr Raquel are available by appointment.

Editor’s Note: This treatment was provided on a complimentary basis for editorial consideration. All views expressed are the writer’s own personal experience and do not constitute medical advice. Individual results may vary. Profhilo® Structura is a prescription-only treatment and must be administered by a qualified medical professional. For more information, speak to your doctor or visit All Saint Skin Clinic.